A thioredoxin-mimetic peptide exerts potent anti-inflammatory, antioxidant, and atheroprotective effects in ApoE2.Ki mice fed high fat diet - Maladies génétiques d'expression pédiatrique Access content directly
Journal Articles Cardiovascular Research Year : 2019

A thioredoxin-mimetic peptide exerts potent anti-inflammatory, antioxidant, and atheroprotective effects in ApoE2.Ki mice fed high fat diet

Abstract

Time for primary review: 40 days Aims Oxidative stress and inflammation play a pathogenic role in atherosclerosis. Thioredoxin-1 (Trx-1) is an antioxidative, anti-inflammatory protein with atheroprotective effects. However, in vivo cleavage of Trx-1 generates a truncated pro-inflammatory protein, Trx-80, which compromises the therapeutic use of Trx-1. Here we analysed whether the thioredoxin-mimetic peptide (TxMP), CB3 might exert anti-oxidative, anti-inflammatory, and atheroprotective effects in ApoE2.Ki mice.
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Dates and versions

inserm-03978156 , version 1 (08-02-2023)

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Fanny Canesi, Véronique Mateo, Dominique Couchie, Sonia Karabina, Anne Nègre-Salvayre, et al.. A thioredoxin-mimetic peptide exerts potent anti-inflammatory, antioxidant, and atheroprotective effects in ApoE2.Ki mice fed high fat diet. Cardiovascular Research, 2019, 115 (2), pp.292-301. ⟨10.1093/cvr/cvy183⟩. ⟨inserm-03978156⟩
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