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Journal Articles (Review Article) Macromolecules Year : 2022

Multicompartment Vesicles: A Key Intermediate Structure in Polymerization-Induced Self-Assembly of Graft Copolymers

Abstract

The morphological evolution of graft copolymer-based nano-objects was monitored by light scattering and electron microscopy during their formulation in water by polymerization induced self-assembly using a photo-mediated reversible addition–fragmentation chain transfer mechanism. The copolymer models used were composed of a dextran backbone bearing poly(2-hydroxypropyl methacrylate) grafts of two degrees of polymerization (X). At a full monomer conversion, unilamellar vesicles (ULVs) and large compound nano-objects (LCNs) were formed when targeting X = 100 and 500, respectively. For X = 100, some spherical, worm-like, then jellyfish-like structures were progressively observed before the ULVs formation. For X = 500, electron cryotomography revealed an unprecedented intermediate morphology formed from the onset of self-assembly called a multicompartment vesicle (MCV) that fused to form LCN. The formation of MCV was attributed to a local phase separation between dextran and the residual 2-hydroxypropyl methacrylate inducing the appearance of multiple hydrophilic cores
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Dates and versions

hal-04038974 , version 1 (21-03-2023)

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Djallal Ikkene, Ana Andreea Arteni, Claire Boulogne, Jean-Luc Six, Khalid Ferji. Multicompartment Vesicles: A Key Intermediate Structure in Polymerization-Induced Self-Assembly of Graft Copolymers. Macromolecules, 2022, 55 (11), pp.4268-4275. ⟨10.1021/acs.macromol.2c00561⟩. ⟨hal-04038974⟩
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