This study aims to analyze spatio-temporal piezometric data and integrate them with geological, geotechnical, and geophysical data to enhance their interpretation. The research focuses on a site located in the Meuse and Haute-Marne departments of France, which has been under investigation since 1994 as part of the surface facilities characterization for the Meuse-Haute-Marne underground laboratory and the CIGEO (Centre Industriel de stockage Géologique) Andra project. These investigations span different spatial and temporal scales. We observed the contribution of water masses associated with external forcing and identified two types of aquifer responses: a rapid response to rainfall events when fractures are well-connected, and minor reactivity at the matrix level. Additionally, we demonstrated that the matrix compartment can be finely characterized through a combined interpretation of piezometric response analysis, fracture analysis, and surface nuclear magnetic resonance (SNMR) soundings. The methodology developed in this project offers an improved understanding of karst piezometry and/or unsaturated zone extension, which is essential for comprehend ding flow dynamics and better constraining the functioning of karst aquifers. Furthermore, this site serves as an ideal workshop for studying flow in fractured media, providing valuable insights into hydrodynamic behavior in complex subsurface environments.